| abstract |
The present invention relates to the induction of hypothermia in humans, male and female, at any age, in a predictable and dose responsive fashion by use of a pharmaceutical composition comprising a combination of two or more compounds selected among (1) vanilloid receptor agonists, capsaicinoids or capsaicinoid-like agonists reaching and binding to vanilloid receptors, and (2) cannabinoids or cannabimimetic agonists reaching and binding to cannabinoid receptors, and (3) adenosine receptor agonists, and (4) neurotensin receptor agonists, and (5) thyroxine derivatives, and (6) cytochrome c inhibitors, and (7) oxygen tension reducers, with the proviso that if the first compound is (1) then the second is not (2), thereby inducing hypothermia, thus benefiting patients suffering from illnesses characterized by tissue anoxia. |