http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2010096201-A2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8c46a3cf34ca1d579fb9b46442956c59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_264acb9fb71956599dbf218ffea30426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d7ab7cf39d1e9e75496dec2e09d8bf21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d21f819e68aafe82fbb84b29e09ec7d2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bca41eda70a68a5dba594ff409e12c3b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-115 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-02 |
| filingDate | 2010-02-23^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9f6d8461db5f6ddf0ad3ce27ff99158 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cd7a37d3cf2777dd80217e636cdcea9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8161a379bcedce9f73d88cb3ee4e3311 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_775ec69aa0998a503b4ef7ac80aa215c |
| publicationDate | 2010-08-26^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2010096201-A2 |
| titleOfInvention | Synthesis of ara-2'-o-methyl-nucleosides, corresponding phosphoramidites and oligonucleotides incorporating novel modifications for biological application in therapeutics, diagnostics, g- tetrad forming oligonucleotides and aptamers |
| abstract | The present invention relates to synthesis, purification and methods to obtain high purity novel 2'-arabino-O-methyl nucleosides and the corresponding phosphoramidites of various arabinonucleoside bases and introduction of such units into defined sequence synthetic DNA and RNA. Various synthetic oligonucleotides, such as HIV integrase inhibitor 14-mer and thrombin binding oligonucleotide, thrombin -1, bearing ara-2'-omethyl modification have been synthesized. It is anticipated the oligonucleotides incorporating these monomers will exhibit biological activities related to antisense approach approach, design of better SiRNA's, diagnostic agents. Similarly, it is anticipated that oligonucleotides incorporating such novel nucleosides will be useful to develop therapeutic candidates designing stable G-quadruplexes and Aptamers for oligonucleotide structure, folding topology, evaluation of biochemical properties and design and develop as therapeutic agents. It is further anticipated that the nucleosides, phosphates and triphosphates of this invention could develop as therapeutic agents. |
| priorityDate | 2009-02-22^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Showing number of triples: 1 to 1000 of 2190.
| Next Page | Last Page |