http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011012800-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bec0ce8e73e5954935089af1dea21933 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a9e6421e9257148abad101e1ce6c162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7ca9ffc860ffc8b469cb88dc8554f38f http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bd00b421583e1effe1518d0fd994f2c9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 |
| filingDate | 2010-07-23^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e3853743f0a510b17cf789d69289a672 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_66d750a6c01b5d9a830e2d0c81ea8b85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03cd5835005f2fe4d21bc2318056f1c9 |
| publicationDate | 2011-02-03^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2011012800-A1 |
| titleOfInvention | Tetrahydroquinoxaline urea derivatives, preparation thereof, and therapeutic use thereof |
| abstract | The invention relates to compounds of formula (I), where: A is a bond, an oxygen atom, or an O-CH 2 - group; Ar 1 is a phenyl or heteroaryl group; Ar 2 is a phenyl, heteroaryl, or heterocycloalkyl group; R 1a,b,c and R2a,b,c are a hydrogen or halogen atom, or an alkyl, cycloalkyl, or alkyl-cycloalkyl group optionally substituted by one or more halogen atoms, or an -OR 5 (hydroxy or alkoxy), hydroxy-alkyl, alkoxy-alkyl, alkoxy-alkoxy, halogenoalkyl, -O-halogenoalkyl, oxo, -CO-alkyl, -CO-alkyl-NR 6 R 7 , -CO-halogenoalkyl, -COOR 5 , alkyl-COOR 5 , -O-alkyl-COOR 5 , -SO 2 -alkyl, -SO 2 -cycloalkyl, -SO 2 -alkyl-cycloalkyl, -SO 2 -alkyl-OR 5 , -SO 2 -alkyl-COOR 5 , -SO 2 -alkyl-NR 6 R 7 , -SO 2 -halogenoalkyl, alkyl-SO 2 -alkyl, -SO 2 -NR 6 R 7 , -SO 2 -alkyl-O-alkyl-OR 5 , -CONR 6 R 7 , -alkyl-CONR 6 R 7 , or O-alkyl-NR 6 R 7 group, or further R 1a , R 1b , and R 1c are bonded to R 2a , R 2b , R 2c , respectively, as well as to the carbon atom having same, and are O-alkyl-O-; R 3 is a hydrogen atom or an alkyl group; R 4 is a CONR 6 R 7 group, a hydroxyalkyl group substituted by a halogenoalkyl group, or an alkyl-NH-SO 2 -alkyl, NH-SO 2 -alkyl, -O-SO 2 -NR 6 R 7 , -alkyl-CO-NR 6 R 7 , -O-alkyl-CO-NR 6 R 7 , -alkyl-NR 6 R 7 , -O-CO-NR 6 R 7 , -alkyl-heteroaryl, a heteroaryl group optionally substituted by an alkyl, alkoxy-imino, or CO-NH-NH-CO-alkyl group, with the proviso that R 4 is in the cis position when it is the CONR 6 R 7 group and that R 6 and R 7 are each hydrogen, or an alkyl or alkyl-phenyl group; R 5 is hydrogen, an alkyl group, or alkyl-phenyl; R 6 and R 7 , identical or different, are each a hydrogen atom, an alkyl group, alkoxy, or an alkyl-phenyl group; and R 8 is a hydrogen atom or an SO 2 -alkyl group, or a group of formula B-Het, where B can be absent or be a bond, an oxygen atom, or a CO- or SO 2 -(CH 2 ) n group, with n being equal to 0, 1, or 2, and where Het is a heteroaryl or heterocycloaryl optionally substituted by the alkyl, -SO 2 -alkyl, and -COOR 5 groups. The invention also relates to a method for preparing same to the therapeutic use thereof. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8796468-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8822452-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2518051-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8524894-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2518051-A4 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8901316-B2 |
| priorityDate | 2009-07-27^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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