| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_459549086df37b5bed0003502de7e7aa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96e719fb3eff234ea7dc7e272d97924d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_585d0f8064213b64ef38c977a4016fc8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b9c9e8e2a8d5efb6b2bdb526a0e542b9 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-42 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-42 |
| filingDate |
2011-02-16^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8672adb1eda40c19f53bc1d5390d9877
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d19d16ac9647dbc9329ef732132bc90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ec0ee1c2a42e4f8464fb32ef0818bd67 |
| publicationDate |
2011-09-09^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2011107843-A2 |
| titleOfInvention |
Process for the preparation of atazanavir sulfate substantially free of diastereomers |
| abstract |
The present invention provides atazanavir sulfate substantially free of diastereomeric impurities. The present invention also provides atazanavir sulfate having D-tertiary leucine analogues less than 0.1%. The present invention further relates to an improved process for preparing atazanavir sulfate, substantially free of its diastereoisomeric impurities, which comprises of reacting diamino compound (IV) with N-methoxycarbonyl-(L)-tertiary-leucine (V) having D-isomer less than 0.1 % to obtain atazanavir base; conversion of atazanavir base to atazanavir sulfate by reacting with sulfuric acid and crystallization of atazanavir sulfate from suitable organic solvent(s). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105503705-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105503705-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104163787-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-115215792-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-113603634-A |
| priorityDate |
2010-03-01^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |