| abstract |
Disclosed are inhibitors of human 12-lipoxygenase of Formula (I) or (II), wherein R 1 , R 2 , R 3 , and R 4 are as defined herein, that are useful in treating or preventing a 12-lipoxygenase mediated disease or disorder, e.g., diabetes. Also disclosed are a composition comprising a pharmaceutically acceptable carrier and at least one inhibitor of the invention, and a method of treating or preventing such disease or disorder in a mammal. |