| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_61f88efcda59d7062a4252ecf6886f58
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_529bc7210a09e4b91ed3272a853d7a20 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-5158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-2302 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001151
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001168
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0636
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001191
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001188
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001192
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001156
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001109
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-0011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-001186 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0783 |
| filingDate |
2011-08-15^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d46cdb18b1a39561a51b3005ed3764dd |
| publicationDate |
2012-02-23^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2012024203-A1 |
| titleOfInvention |
Methods of identifying central memory t cells and obtaining antigen-specific t cell populations |
| abstract |
The invention provides a method of obtaining a population of antigen-specific T cells comprising: (i) dividing PBMCs from peripheral blood of a host into more than one sub-population; (ii) contacting the PBMCs of each sub-population with an antigen; (iii) obtaining a sample of the contacted PBMCs from each sub-population; (iv) measuring the quantity of 1) IL-2 mRNA and 2) IFN- γ mRNA expressed by the PBMCs of each sample; (v) determining the IL-2 index of each sample; (vi) identifying one or more samples with an IL-2 index determined in (v) of greater than or equal to about 10 to identify one or more antigen-reactive, central memory T cell sub-populations; (vii) dividing the antigen-reactive, central memory T cell sub-population(s) identified in (vi) into microcultures; (viii) identifying one or more antigen-reactive microcultures; and (ix) expanding the microculture(s). |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3200591-A4
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107404881-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-107404881-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3916084-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3200591-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10676717-B2 |
| priorityDate |
2010-08-18^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |