http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2012068107-A2

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filingDate 2011-11-15^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dff05dffa4cb9e7a64bd3786af91c422
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publicationDate 2012-05-24^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2012068107-A2
titleOfInvention Autoantibody to rna-protein complex detected by quantitative pcr
abstract The disclosure provides methods of detecting an autoantibody from a serum sample from a human or animal that is specific for an RNA:protein complex, the method comprising the steps of: (a) obtaining an immunoglobulin-RNA:protein aggregate, wherein said aggregate can comprise a target RNA:protein complex and an RNA:protein complex-specific antibody; (b) isolating the RNA from the immunoglobulin-RNA-protein aggregate; and (c) detecting the isolated RNA by quantitative reverse transcription PCR, whereby detection of the RNA can indicate the presence of the RNA:protein complex-specific antibody in a subject human or animal. One example of the method is configured for the detection of autoantibodies specifically binding to a U3 RNA: protein complex.
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