abstract |
Disclosed is a novel method for synthesizing a rivaroxaban intermediate, 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazoligdin-3-yl]phenyl}morpholin-3-one. The novel method provided in the present invention is provided with mild reaction conditions, convenient operations, facilitated purification, reduced production costs, and is environmental friendly and suitable for industrial production. |