| abstract |
The present invention relates to a camptothecin derivative having a structure as represented by Formula (II), in which X n+ is selected among H + , K + , Na + , Li + , Mg 2+ , Ca 2+ , Zn 2+ , Fe 3+ , and ammonium, while R 1 , R 2 , R 3 , and R 4 individually represent a hydrogen, a nitro group, a nitrile group, a halogen, a carboxyl group, an optionally substituted amino group, a substituted silicon group, a monocyclic aryloxy group, an optionally substituted C1-C6 alkoxy group, an optionally substituted C1-C6 alkylcarbonyl group, an optionally substituted C1-C6 alkyl group, or an optionally substituted C1-C6 cycloalkyl group; alternatively, R 1 and R 2 are connected via one to three other atoms to form a heterocyclic ring; and in another embodiment, R 3 and R 4 form a cyclic compound via -O-(CH2)n-O-, in which n = 1 or 2. The compound is provided with great aqueous solubility, compound stability, and great efficacy in treatment of cancer. [Formula (II)] |