| abstract |
The present invention relates to an agent for treating or controlling the recurrence of acute myelogenous leukemia, and to an agent for controlling leukemic stem cell propagation, which comprise a compound or salt thereof represented by the following formula (I). (In the formula, Ar 1 and Ar 2 are aryl or heteroaryl groups; L is O, S, NH, NHCO or CONH; X is CH or N; Y is a C 1-3 alkylene; Z 1 is hydrogen or a C 1-6 alkyl, amino-C 1-6 -alkyl, C 1-6 -alkylamino-C 1-6 -alkyl, di(C 1-6 -alkyl)amino-C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, C 1-6 -alkoxy-C 1-6 -alkyl, or carboxy-C 1-6 -alkyl; Z 2 is a C 1-6 -alkyl, amino-C 1-6 -alkyl, C 1-6 -alkylamino-C 1-6 -alkyl, di(C 1-6 -alkyl)amino-C 1-6 -alkyl, hydroxy-C 1-6 -alkyl, C 1-6 -alkoxy-C 1-6 -alkyl, or carboxy-C 1-6 -alkyl; and, together with adjacent nitrogen atoms, Z 1 and Z 2 can form a heterocyclic group wherein in addition to the nitrogen atoms adjacent to Z 1 and Z 2 , one or more hetero atoms are contained in the ring members.) |