http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2014111456-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6239ff6fe13e938cdf6854d9e1d1dee7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-68 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2014-01-16^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcb71406c1c01f70ae8a8ec1d3451ea4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b33d17ecfd7118b8f6eeb9a0e9ac1cd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c48fb5c8fd852e4dcfacf8dfa1c4218b |
| publicationDate | 2014-07-24^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2014111456-A1 |
| titleOfInvention | Method to screen for the teratogenic potential of substances |
| abstract | The present invention relates to co-crystal forms of a bacterial cereblon homologue together with thalidomide, crystal structure information obtained from them, methods of preparing such co-crystal forms. The invention refers further to an in vitro method to analyze the teratogenic potential of substances, preferably pharmaceutically active substances, via their binding to the protein cereblon, a cellular target of thalidomide, and refers to the substrate 1-(N-2-MANT-imidoethyl)-uracil as well as a mutant bacterial cereblon homologue from Magnetospirillum n gryphiswaldense both specifically designed for carrying out the inventive method. |
| priorityDate | 2013-01-16^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Showing number of triples: 1 to 197 of 197.