| abstract |
The invention provides compound (I): wherein each symbol is as defined in the specification, having a tyrosine kinase inhibitory action on Trk receptors such as TrkA, TrkB, TrkC or other tyrosine kinase receptors such as Flt-3, which is useful for the prophylaxis or treatment of proliferative diseases associated with kinase signaling pathway such as tumor or cancer, fibrotic diseases, restenosis associated with angioplasty, polycystic kidney disease, aberrant angiogenesis disease, tuberous sclerosis complex, hair loss, and Alzheimer's disease. |