http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015018755-A1

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publicationDate 2015-02-12^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2015018755-A1
titleOfInvention Apparatus and method for calibrating acoustic desynchronizing neurostimulation
abstract An apparatus for stimulating neurons, comprising a stimulation unit for applying pulse-like tones, a measuring unit for picking up measurement signals that render neural activity by the stimulated neurons, a control and analysis unit for controlling the stimulation unit and for analysing the measurement signals, wherein the control and analysis unit is embodied such that it applies a first pulse train having varied pitch, takes the measurement signals picked up in response to the first pulse train as a basis for selecting at least one first pitch range or pitch in which there is phase synchronisation between the pulse train and the neural activity, actuates the stimulation unit such that it applies two phase-shifted second pulse trains, the pitch of the pulse trains being varied in opposite directions and a starting value for the pitch of the second pulse trains being chosen on the basis of the at least one first pitch range or pitch, and takes this as a basis for responding by selecting a second pitch range or pitch in which the amplitude of the neural activity is at a minimum.
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