| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cd149ada3d79f4bce9b80274444170f7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-16 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6897
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-191
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-703
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-70 |
| filingDate |
2014-10-01^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a14129f55fd8d2744ba14541c50751f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73209e4aedf42639dc3d3e0ea92ed55e |
| publicationDate |
2015-04-09^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2015051035-A1 |
| titleOfInvention |
Compositions, systems and methods for gene expression noise drug screening and uses thereof |
| abstract |
HIV-1's ability to enter a transcriptionally dormant state and establish a reservoir of latently infected cells is considered the major barrier to eradicating the virus from infected patients. Stochastic noise (i.e. fluctuations) in an HIV-1 transcriptional positive-feedback loop is one mechanism that enables HIV-1 to establish latency. Here, Applicants demonstrate that small-molecule modulation of noise in HIV-1 gene expression radically perturbs HIV-1 latency. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111304312-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112043724-B
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112043724-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106265679-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017141137-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-111304312-B |
| priorityDate |
2013-10-01^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |