http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2016020635-A1

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filingDate 2015-06-16^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a0909fca0c0b412546b8a1145078212e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2fe00f10f69350f78b4085d6b3d975e0
publicationDate 2016-02-11^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2016020635-A1
titleOfInvention Chlorination of sucrose-6-esters
abstract There is provided a method for the chlorination of a sucrose-6-acylate to produce a 4,1',6'-trichloro-4,1',6'-trideoxy-galactosucrose-6-acylate, wherein said method comprises the following steps (i) to (v): (i) providing a first component comprising sucrose-6-acylate; (ii) providing a second component comprising a chlorinating agent; (iii) combining said first component and said second component to afford a mixture; (iv) heating said mixture for a heating period in order to provide chlorination of sucrose-6-acylate at the 4, 1' and 6' positions thereof; (v) quenching said mixture to produce a 4,1',6'-trichloro-4,1',6'-trideoxy- galactosucrose-6-acylate; wherein at least one of said first component and said second component comprises a reaction vehicle, and said reaction vehicle comprises a tertiary amide; and wherein said mixture comprises a cosolvent during a least a portion of the heating period of step (iv), wherein said cosolvent comprises dimethylacetamide (DMAc).
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priorityDate 2014-08-08^^<http://www.w3.org/2001/XMLSchema#date>
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