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filingDate 2014-09-24^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d6e07da68b1b80ecbaf8a3d3c28769f
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publicationDate 2016-03-31^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2016048299-A1
titleOfInvention Cancer-associated fibroblasts in maintaining stemness of cancer stem cells
abstract An in vitro co-culture system comprising cancer-associated fibroblasts (CAFs) and cancer cells for producing and maintaining cancer stem cells and uses thereof for identifying agents capable of reducing cancer cell stemness. Also disclosed herein are a paracrine network through which CAFs facilitate production and/or maintenance of cancer stem cells and the use of components of such a paracrine network for prognosis purposes and for identifying cancer patients who are likely to respond to certain treatment.
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP51748
http://rdf.ncbi.nlm.nih.gov/pubchem/compound/CID148124

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