http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017001333-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8b0395805ee2352a18a9d72ac99ab524 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-6454 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1029 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-64 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-345 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-10 |
| filingDate | 2016-06-27^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_305cb426b8b0f1b1c2c0f30373249899 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba4a7b7fddfb4d7a31b433e7046973f1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f319178efd75d649e89073cfeb02d4a0 |
| publicationDate | 2017-01-05^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | WO-2017001333-A1 |
| titleOfInvention | Microbiological production of short fatty acids and uses thereof |
| abstract | The present invention relates to proteins involved in fatty acid synthesis, such as fatty acid synthases (FAS) variants, comprising one or more polypeptide chains, wherein said polypeptide chain(s) comprise one or more subunits comprising a malonyl/palmitoyl transferase domain (MPT domain), acetyl transferase domain (AT domain), and/or ketoacyl synthase domain (KS domain), and at least one amino acid substitution in the MPT domain at a position corresponding to R90, in the AT domain at a position corresponding to I151, and/or in the KS domain, preferably in the acyl binding channel, to modulate affinities of acyl intermediates, and optionally further amino acid substitution(s). The present invention relates to the respective polypeptide domains. The present invention further relates to nucleic acid molecules encoding the proteins (or the polypeptide domains) and to host cells containing said nucleic acid molecules. The present invention further relates to a method for the production of short fatty acids, CoA esters of short fatty acids, ethyl esters of short fatty acids, esters of short fatty acids with other metabolites, and/or enzyme bound short fatty acids (C 6 to C 12 ), comprising the expression of said nucleic acid molecules, preferably in said host cells. The present invention further relates to a method for the production of biofuels, flavoring compounds and/or fine chemicals, comprising the expression of said nucleic acid molecules, preferably in said host cells. The present invention also relates to the use of the proteins, nucleic acids molecule or host cells for the production of short fatty acids (C 6 to C 12 ), the production of CoA esters of short fatty acids (C 6 to C 12 ), the production of ethyl esters of short fatty acids (C 6 to C 12 ), the production of esters of short fatty acids (C 6 to C 12 ) with other metabolites, the production of enzyme bound short fatty acids (C 6 to C 12 ), the production of biofuels, fine chemicals and/or flavoring substances. |
| priorityDate | 2015-06-29^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Showing number of triples: 1 to 783 of 783.