| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_468ba69b8e2068e9319b9942dcc081b3 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-36157
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-36167
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-36153
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-36178 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-36146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-36171
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-36175
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-36064
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61N1-0534 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N1-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N1-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N1-05
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N1-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61N1-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61M37-00 |
| filingDate |
2016-09-15^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0485e67309d3343d7b74c65b1b1990f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c873cbf5f107771a5d78eea4c0ce767a |
| publicationDate |
2017-03-23^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2017048908-A1 |
| titleOfInvention |
Stimulation of the ventral pallidum for the treatment of epilepsy |
| abstract |
Deep brain stimulation of the ventral pallidum (VP-DBS) prevents or potently attenuates epileptiform activity and behavioral seizures. VP-DBS prior to pilocarpine prevented behavioral partial and generalized forebrain seizures and generalized brainstem seizures in most animals. VP-DBS after brainstem seizures emerged prevented or reduced the appearance of subsequent behavioral and electrographic brainstem seizures. Even if VP-DBS was turned on after partial forebrain seizures started, this timed approach could still reduce partial forebrain seizures but also prevented secondarily generalized forebrain seizures. Epileptiform activity in brainstem areas, especially in the nucleus of the solitary tract (NTS) which controls cardiovascular function, was prevented by VP-DBS. Altogether, VP-DBS is a therapeutic approach for individuals with intractable epilepsy with partial and/or generalized seizures and may potentially prevent or diminish sudden unexpected death in epilepsy (SUDEP) by preserving activity of brainstem neurons involved in cardio-respiratory function. |
| priorityDate |
2015-09-17^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |