| abstract |
Disclosed are an FXR agonist and a preparation method and use thereof, in particular relating to the compound having the structure of formula (I), a stereisomer or a pharmaceutically acceptable salt thereof. The series of compounds can be used to treat FXR mediated diseases, comprising cardiovascular disease, atherosclerosis, arteriosclerosis, hypercholesterolemia, hyperlipidemia and chronic hepatitis, chronic liver disease, gastrointestinal diseases, kidney diseases, metabolic diseases, cancers (such as colorectal cancer) or neurological conditions such as strokes etc., have a wide medical application, and have a promising future for being developed into a new generation of FXR regulating agents. |