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filingDate 2017-10-31^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2018-05-03^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2018081788-A1
titleOfInvention Methods of enhancing translation ability and stability of rna molecules, treatments, and kits
abstract The present invention relates to methods of enhancing the translation ability and stability of an RNA molecule. The methods involve providing a cell-free composition comprising an RNA molecule to be translated, where the RNA molecule lacks an N 6 ,2'O- dimethyladenosine ("m 6 A m ") residue. Also disclosed are methods of making RNA molecules and treatment methods using an RNA molecule comprising a 7-methylguanosine ("m 7 G"), a 5' triphosphate linker ("-ppp-"), and an N 6 ,2'-0-dimethyladenosine (m 6 A m ).
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