| abstract |
The present invention falls within the technical field of medicine and relates to amide and thioamide derivatives and preparation methods therefor and the use thereof, and particularly relates to derivatives of the general formula (I) and geometrical isomers thereof or pharmaceutically acceptable salts, hydrates, solvates and prodrugs thereof and the preparation methods therefor. The derivatives have an activity as protein kinase inhibitors, especially PAK kinase inhibitors. |