| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d81f79f831e4b8da788ba698be288ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6f4d86235703b3e2a1cb10b98722d80d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_37f4922dfb7777b019e504b885211b8e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_43a72884e25aaecffebe0942132d704f |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-50 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57438
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4985
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-277 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-18
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-277
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4985 |
| filingDate |
2018-03-16^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9359edd26c76f96d8abd626b85866b9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fad13418313b7e33939d867fa5c12be3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a27e2dd614eb400f03ce90bffe0dab93 |
| publicationDate |
2018-09-20^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2018167283-A1 |
| titleOfInvention |
Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling |
| abstract |
The present invention relates to the diagnosis and treatment of pancreatic ductal adenocarcinoma (PDA) associated neural remodeling (PANR). The inventors investigated the effects of the stromal compartment on PDA and PANR and the specific connection between the stromal compartment and the nerve system in PDA. Using PDA samples from human and endogenous mouse models, the inventors demonstrated that LIF (leukemia inhibitory factor) is overexpressed in PDA tissues compared to healthy pancreas while its receptors, LIFR and gp130, are expressed in intra-tumoral nerves. The inventors demonstrated that LIF expression and secretion induced Schwann cell migration, decreased proliferation and modulated their differentiation status. LIF also induced neuronal plasticity. The injection of LIF blocking antibody in endogenous PDA mice model reduces intra-tumoral nerve density. Furthermore, using human and mouse serum libraries, the inventors showed that LIF titer improves CA19.9 diagnostic value and is positively correlated with intra-tumoral nerve density. Thus, the present invention relates to LIF inhibitor for use in the treatment of PANR and a method of identifying a subject having or at risk of having or developing PANR, comprising measuring the expression level of LIF. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11098095-B1 |
| priorityDate |
2017-03-17^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |