| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_360c4f94de60f656bad8ee4ea34f8e2c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5cda553584be20ec7b9e8ab68b867b1c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_35ede05b702220a0d65df851cfb6f1ff
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a799d17d5f808bee28dc9a15345a54f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C253-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D271-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-61 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D271-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C13-465
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C209-22 |
| filingDate |
2018-09-20^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ffcebc85569c8a83bb0984e72de1bec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0bb2af10bb87061da934a239fe152525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c60a2fd2481a018badff90463ffbc07c |
| publicationDate |
2019-03-28^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
WO-2019058290-A1 |
| titleOfInvention |
IMPROVED PROCESS FOR THE PREPARATION OF AZANIMOD A-AMINO COMPOUND |
| abstract |
The present invention relates to an improved process for the preparation of an optically active chiral amino compound. The present invention relates in particular to an improved process for the preparation of (S) -1-amino-2,3-dihydro-1H-indene-4-carbonitrile, an important intermediate for the synthesis of ozanimod. The present invention relates more particularly to the preparation of (S) -1-amino-2,3-dihydro-1H-indene-4-carbonitrile using 4-cyano-1-indanone and alpha-methylbenzylamine derivatives. as raw materials. The present invention particularly relates to the preparation of (S) -1-amino-2,3-dihydro-1H-indene-4-carbonitrile comprising a synthesis of diastereoselective chiral amine by protection with chiral auxiliary -methyl benzylamine derivatives followed reduction and debenzylation. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110229067-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4212156-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11465977-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020064818-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023135207-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2021084068-A1 |
| priorityDate |
2017-09-20^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |