http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019107516-A1

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filingDate 2018-11-29^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_15981921f3c3d49f6e517fcf3d6d5c12
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publicationDate 2019-06-06^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2019107516-A1
titleOfInvention GENE-MODIFIED MICROORGANISM FOR PRODUCING 3-HYDROXYADIPIC ACID, α-HYDROMUCONIC ACID AND/OR ADIPIC ACID, AND PRODUCTION METHOD FOR SAID CHEMICAL PRODUCTS
abstract Disclosed is a gene-modified microorganism wherein nucleic acids have been introduced which code for an enzyme catalyzing a reaction which reduces 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA. In the gene-modified microorganism, either: nucleic acids have been introduced which code for polypeptides described in (a)-(c) below; or, the expression of the polypeptides is enhanced. (a) A polypeptide formed from any amino acid sequence from SEQ ID NO:1-6 and 213, (b) a polypeptide comprising any of the amino acid sequences from SEQ ID NO:1-6 and 213 in which at least one amino acid has been substituted, deleted, inserted and/or added, said polypeptide having enzyme activity catalyzing a reaction which reduces 3-oxoadipyl-CoA to generate 3-hydroxyadipyl-CoA, and (c) a polypeptide having at least 70% sequence identity with any of the amino acid sequences from SEQ ID NO:1-6 and 213, said polypeptide having activity which reduces 3-oxoadipyl-CoA to generate 3-hydroxyadipyl-CoA.
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