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publicationDate 2019-11-07^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2019211472-A1
titleOfInvention Antibody variant combinations and uses thereof
abstract Provided herein are combinations of first and second antibodies having modified Fc effector functions resulting from amino acid substitutions in the Fc region, the amino acid substitutions allow for co-dependent activation of effector functions such as CDC and/or ADCC. Also provided are combinations of first and second antibodies having agonistic activity or enhanced agonistic activity resulting from amino acid substitutions in the Fc region where the agonistic activity is co-dependent of both a first and second antibodies.
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http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP49875
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID24954
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCF1NNP2
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID281626
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ8MKH0
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID743963
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID3635237
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCP05016
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ08081
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID373904
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID664779

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