| abstract |
The present invention relates to crystal modifications of 1,1-dioxo-3,3-dibutyl-5-phenyl-7- methylthio-8-(N-{(R)-α-[N-((S)-1-carboxypropyl)carbamoyl]-4-hydroxybenzyl}carbamoylmethoxy)- 2,3,4,5-tetrahydro-1,2,5-benzothiadiazepine (odevixibat), more specifically crystal modifications and 2 of odevixibat. The invention also relates toa process for the preparation of crystal modification 1 of odevixibat, toa pharmaceutical composition comprising crystal modification 1, and to the use of this crystal modification in the treatment of various conditionsas described herein. |