| abstract |
Provided are a nucleic acid nanocarrier medicine and a preparation method therefor. The medicine comprises nucleic acid nanoparticles and medicine components. The medicine components are mounted on the nucleic acid nanoparticles and comprise dihydroartemisinin, cisplatin, oxaliplatin, flavonoid or vincristine. The nucleic acid nanoparticles comprise a nucleic acid domain, and the nucleic acid domain comprises sequence a, sequence b and sequence c. The sequence a comprises sequence a1 or a sequence in which at least one base of the sequence a1 is inserted, deleted or replaced; the sequence b comprises sequence b1 or a sequence in which at least one base of the sequence b1 is inserted, deleted or replaced; and the sequence c comprises sequence c1 or a sequence in which at least one base of the sequence c1 is inserted, deleted or replaced. The provided nucleic acid nanocarrier medicine has good targetability after the nucleic acid domain is modified by a target and may stably deliver the medicine components, thereby being highly reliable. |