http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020264188-A1

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filingDate 2020-06-25^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2020-12-30^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2020264188-A1
titleOfInvention Reactive dry powdered hemostatic materials comprising a nucleophile and a multifunctional modified polyethylene glycol based crosslinking agent
abstract Compositions and methods related to powdered hemostats that crosslink during and/or after application to a bleeding site are described. The compositions may comprise a first component comprising a polyalkylene oxide-based polymer functionalized with electrophilic reactive groups, and a second component that comprises a protein such as albumin and an optional crosslinking initiator — which may be a base or basic salt such as sodium bicarbonate. The compositions may in certain applications act as hemostats when applied in dry powder form to a bleeding wound, whereupon the first component and the second component of the composition crosslink to form a hydrogel.
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