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publicationDate 2021-11-18^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-2021229238-A1
titleOfInvention Anti-infective bicyclic peptide ligands
abstract The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which are high affinity binders of ACE2. The invention also includes pharmaceutical compositions comprising said polypeptides and to the use of said polypeptides in suppressing or treating a disease or disorder mediated by ACE2, such as infection of COVID-19 or for providing prophylaxis to a subject at risk of infection of COVID-19.
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