| abstract |
An SOS1 degrading agent and a preparation method therefor and an application thereof. Specifically, disclosed is a compound represented by formula I: S-L-E(I), wherein L is a linker chain, which connects S and E by means of covalent bonds; E is the small molecule ligand of an E3 ubiquitin ligase complex. The compound represented by formula I is capable of degrading and/or inhibiting an SOS1 protein in cells, and can be used to treat and/or prevent related diseases or disorders mediated by SOS1, or caused by an interaction between SOS1 and Ras or between SOS1 and Rac. |