| abstract |
Antimicrobial dithiocarbamoyl quinolone compounds of general formula (I), wherein A?1, A?2, A?3, R?1, R?3, R?4, and R?6 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and R?1 is X, R?3 is X, or both R?1 and R?3 are X; and X is -R?15-N(R?16)(R?17) or -R?15-R?18-N(R?19)(R?17), where R?15 is nil, alkyl, a carbocyclic ring, or a heterocyclic ring; and R?16 is hydrogen, alkyl, alkenyl, a carbocyclic ring, a heterocyclic ring; or when X is R?15-N(R?16)(R?17), R?16 and R?15 may together comprise a heterocyclic ring including the nitrogen atom to which R?15 and R?16 are bonded; R?17 is C(=S)-S-M, where M is a pharmaceutically acceptable salt or biohydrolyzable ester; and R?18 is alkyl, a carbocyclic ring, or a heterocyclic ring; and R?19 is hydrogen, alkyl, alkenyl, a carbocyclic ring, a heterocyclic ring; or R?18 and R?19 may together comprise a heterocyclic ring including the nitrogen atom to which R?18 and R?19 are bonded; and pharmaceutically-acceptable salts and biohydrolyzable esters thereof, and hydrates thereof. |