| abstract |
Compounds of general formula (I) wherein R1 represents a hydrogen atom or a C¿1?-C6 alkyl, C1-C6 alkenyl, phenyl, phenyl(C1-C6)alkyl, C1-C6 alkylthiomethyl, phenylthiomethyl, substituted phenylthiomethyl, phenyl(C1-C6)alkylthiomethyl or heterocyclylthiomethyl group; or R?1¿ represents -S-Rx wherein Rx represents a group α; R2 represents a hydrogen atom or a C¿1?-C6 alkyl, C1-C6 alkenyl, phenyl(C1-C6)alkyl, cycloalkyl(C1-C6)alkyl, or cycloalkenyl(C1-C6)alkyl; R?3¿ represents an amino acid side chain or a C¿1?-C6 alkyl, benzyl, (C1-C6)alkoxybenzyl, benzyloxy(C1-C6)alkyl or benzyloxybenzyl group; R?4¿ represents a hydrogen atom or a methyl group; R5 represents a group (CH¿2?)nA; or R?4 and R5¿ together represent a group β; Q represents CH¿2? or CO; m is an integer from 1 to 3; n is an integer from 1 to 6; and A represents a hydroxy, (C1-C6)alkoxy, (C2-C7)acyloxy, (C1-C6)alkylthio, phenylthio, (C2-C7)acylamino or N-pyrrolidone group or a salt and/or N-oxide and/or (where the compound is a thio-compound) a sulphoxide or sulphone thereof have collagenase inhibition activity and are useful in the management of disease involving tissue degradation and/or the promotion of wound healing. Diseases involving tissue degradation include arthropathy (particularly rheumatoid arthritis), inflammation, dermatological diseases, bone resorption diseases and tumour invasion. |