| abstract |
1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid compounds of formula (a), in which R1 is carboxy, COO- or protected carboxy, R2 is hydroxy(lower)alkyl or protected hydroxy(lower)alkyl, R8 is hydrogen or lower alkyl, Z is a group of formulae (b) or (c), wherein R3 is hydrogen; lower alkyl or lower alkenyl, each of which is optionally substituted by the group consisting of lower alkoxy, carbamoyl, hydroxy, halogen, mono(or di)(lower)alkylcarbamoyl, mono(or di)(lower)alkenylcarbamoyl, mono(or bis)[hydroxy(lower)alkyl]carbamoyl, optionally substituted cyclic-aminocarbonyl, acylamino, ureido, optionally substituted heterocyclic-carbonylamino, carbamoyloxy, mono(or di)(lower)alkylcarbamoyloxy, lower alkylthio, halo(lower)alkylthio, optionally substituted heterocyclicthio, optionally substituted heterocyclic group, optionally substituted aryl, and acyl; R9 is hydrogen or lower alkyl, and R10 is lower alkyl, or pharmaceutically acceptable salts thereof, which is useful as an antimicrobial agent. |