| abstract |
A compound or prodrug thereof having formula (II), wherein -OR1 comprises the C-13 side-chain of taxol and Z is selected from the group consisting of -CHO, -CH¿2?OH, -CH2OR', -CH2NR'R', -CH=NR', -CH=NOR', -CH=NNR'R', -CH(OH)SO3Na, -CH2OPO3?=, -CH¿2OSO3=, -CN and a radical of formula (a) where X and Y are independently selected from -O-, -S-, and -N(R')-, as well as a method for preparing the compounds of the invention, a method of their use for the inhibition of tumors and pharmaceutical compositions containing the same. |