| abstract |
The present invention provides a method of producing a sustained-release microsphere which comprises emulsification, a physiological active peptide and a pamoic acid by a biodegradable polymer; a sustained-release microsphere comprising an about 0.01 to about 10 νm particle size of a pamoic acid salt of physiologically active peptide and a biodegradable polymer; a sustained-release microsphere comprising a complex or a salt formed by a physiologically active peptide, a pamoic acid or a salt thereof and a biodegradable polymer; and a sustained-release preparation comprising the microsphere. The microsphere contains a large amount of the physiologically active peptide and can regulate a release rate of the physiological peptide. |