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filingDate 1998-04-27^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e0d91c2c99b40ec46f6bbef971ca0a6
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publicationDate 1998-11-05^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber WO-9849197-A1
titleOfInvention Oligopeptidic inhibitors of elastases and methods of preparation thereof
abstract The invention relates to oligopeptidic inhibitors of elastases, with potent inhibition of leukocyte elastase. The inhibitors are isobutylamides of tetra- to pentapeptides which have substituted lysine incorporated in the N-terminal portion of the molecule. This dibasic aminoacid is alternatively substituted at both α- and ε-aminogroups with higher saturated acids or with φ-carboxylalkanoylic residues. In one type of these compounds the ε-aminogroup is acylated with an acyl-alanine, where an acyl means a higher saturated acid. The compounds of this invention are the active components of medicinal preparations used mainly in dental practice.
priorityDate 1997-04-30^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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