| abstract |
The present invention is a method or an apparatus for interactively processing biological cells maintained in a sterile environment. Furthermore, the invention provides a superior system for enzymatically converting red blood cells of groups A, B, or AB to group O. A system (10) for interactively processing biological cells maintained in a sterile environment includes a supply module (20), a cell module (12), a processing module (60), at set of conduits, a plurality of valves, a plurality of sensors and a control module (80). The supply module is constructed and arranged to provide selected amounts of process chemicals. The cell module includes a cell sensor for measuring the amount of the biological cells supplied for processing to the processing module. The processing module is constructed and arranged to process said biological cells. Several conduits connect the supply module, the cell module and the processing module in a sterile manner, and the valves control transfer of the biological cells and the process chemicals between the modules. The sensors are constructed and arranged to detect the transfer of the biological cells and the process chemicals in the conduits. The control module is operatively connected to the valves, the sensors and the processing module. The control module also receives data from the cells sensor and controls the transfer and the processing of the biological cells based on the cell sensor data. The system can adjust the processing algorithm based on the type of the processed cells or the cell amount provided for processing. |