| abstract |
An erythromycin A derivative represented by formula (I), wherein n is an integer of 1 to 7, R1 is a hydrogen atom or an alkyl group, R2 is a quinolyl group, a pyrazinyl group, a benzimidazolyl group, a thiazolyl group, a pyridyl group, a pyrimidyl group, a purinyl group, a triazinyl group, a phenyl group or a naphthyl group, R3 is a hydrogen atom, an alkyl group or a cinnamyl group, R4 is a hydrogen atom, or R?4 and R5¿ together form an oxo group, R5 is a group represented by the formula: -OCO-CH¿2-R?8, -OCO-R8, -OCO-NH-R?8, -O-R8¿ or -OCO-O-R?8; and R6 and R7¿ are each a hydrogen atom or an alkyl group, or a pharmaceutically acceptable salt thereof has a strong antibacterial activity against not only erythromycin-sensitive bacteria but also erythromycin-resistant bacteria. |