| abstract |
Compounds represented by general formula (1') and nociceptin antagonists containing the compounds [1'] as the active ingredient wherein R2 represents optionally hydroxylated lower alkyl, amino, etc.; the ring B represents phenyl, thienyl, etc.; E represents a single bond, -O-, -S-, etc.; the ring G represents aryl, a heterocycle, etc.; R5 represents halogeno, hydroxy, lower alkyl optionally substituted by, for example, halogeno, etc.; t is 0 or an integer of from 1 to 5, provided that when t is 2 to 5, then R5s may be the same or different; m is 0 or an integer of from 1 to 8; and n is 0 or an integer of from 1 to 4. The compounds [1'] exert an analgetic effect on serious pains such as postoperative pain via a nociceptin inhibitory action. Utilization of specific amide derivatives including the compounds [1'] as nociceptin antagonists or analgetic agents. |