› 4ocd

X-ray diffraction
2.1Å resolution

In and Out the minor groove: Interaction of an AT rich-DNA with the CD27 drug

Released:
DOI: 10.2210/pdb4ocd/pdb
PDB entry 4ocd coloured by chain, front view.
PDB entry 4ocd coloured by chain, side view.
PDB entry 4ocd coloured by chain, top view.
Source organism: Synthetic construct
Primary publication:
In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27.
Acosta-Reyes FJ, Dardonville C, de Koning HP, Natto M, Subirana JA, Campos JL
OpenAccess logo Acta Crystallogr D Biol Crystallogr 70 1614-21 (2014)
PMID: 24914972

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-117909 (preferred)
Entry contents:
1 distinct DNA molecule
Macromolecule:
d(AAAATTTT) Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 8 nucleotides
Theoretical weight: 2.42 KDa
Source organism: Synthetic construct
Expression system: Not provided

Ligands and Environments

1 bound ligand:
Ligand MWB 3 x MWB
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALBA BEAMLINE XALOC
Spacegroup: P6122
Unit cell:
a: 78.013Å b: 78.013Å c: 91.552Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.237 0.236 0.251
Expression system: Not provided

Quick links

Citations

6 citation in other articles

Functional and structural analysis of AT-specific minor groove binders that disrupt DNA-protein interactions and cause disintegration of the Trypanosoma brucei kinetoplast.
Millan et al. (2017)
5 more

1 mention without citation

In and out of the minor groove: interaction of an AT-rich DNA with the drug CD27.
Acosta-Reyes et al. (2014)