Version 5.4
Mus musculus Gene: Nhp2
Summary
InnateDB Gene IDBG-170212.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nhp2
Gene Name NHP2 ribonucleoprotein homolog (yeast)
Synonyms 2410130M07Rik; D11Ertd175e; Nola2
Species Mus musculus
Ensembl Gene ENSMUSG00000001056
Encoded Proteins
IDBP-540910
NHP2 ribonucleoprotein homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145912:
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:51619735-51623714
Strand Forward strand
Band B1.3
Transcripts
ENSMUST00000001083
ENSMUST00000127405 ENSMUSP00000120014
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0030515 snoRNA binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0008150 biological_process
GO:0031118 rRNA pseudouridine synthesis
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005732 small nucleolar ribonucleoprotein complex
GO:0005737 cytoplasm
GO:0015030 Cajal body
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000145912
View Gene Order
ENSBTAG00000006374
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_7974
Telomere Extension By Telomerase pathway
REACT_22172
Chromosome Maintenance pathway
REACT_7970
Telomere Maintenance pathway
REACT_115566
Cell Cycle pathway
REACT_8030
Extension of Telomeres pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q9CRB2
TrEMBL
UniProt Splice Variant
Entrez Gene 52530
UniGene Mm.481567
RefSeq NM_026631
OMIM
CCDS CCDS24655
HPRD
IMGT
MGI ID MGI:1098547
MGI Symbol Nhp2
EMBL AK007340 AK008766 AK019134 BC024944
GenPept AAH24944 BAB24973 BAB25882 BAB31561
RNA Seq Atlas 52530

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: [email protected]