IGF1R

IGF1R
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1IGR, 1JQH, 1K3A, 1M7N, 1P4O, 2OJ9, 2ZM3, 3D94, 3F5P, 3I81, 3LVP, 3LW0, 3NW5, 3NW6, 3NW7, 3O23, 3QQU, 4D2R, 4XSS, 5HZN
Dynodwyr
Cyfenwau	IGF1R, CD221, IGFIR, IGFR, JTK13, insulin like growth factor 1 receptor, Insulin-like growth factor 1，IGF-1R
Dynodwyr allanol	OMIM: 147370 HomoloGene: 30997 GeneCards: IGF1R
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • transferase activity • nucleotide binding • protein kinase activity • insulin-like growth factor binding • insulin receptor binding • insulin binding • kinase activity • phosphatidylinositol 3-kinase binding • insulin-like growth factor-activated receptor activity • GO:0001948, GO:0016582 protein binding • identical protein binding • transmembrane receptor protein tyrosine kinase activity • insulin receptor substrate binding • protein tyrosine kinase activity • ATP binding • insulin-like growth factor I binding • insulin-activated receptor activity Cydrannau o'r gell • integral component of membrane • bilen • intracellular membrane-bounded organelle • receptor complex • Cellbilen • integral component of plasma membrane • alphav-beta3 integrin-IGF-1-IGF1R complex • insulin receptor complex • axon Prosesau biolegol • GO:1901047 insulin receptor signaling pathway • insulin-like growth factor receptor signaling pathway • phosphorylation • transmembrane receptor protein tyrosine kinase signaling pathway • positive regulation of cell migration • negative regulation of apoptotic process • protein tetramerization • positive regulation of DNA replication • protein phosphorylation • regulation of JNK cascade • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response • positive regulation of cell population proliferation • peptidyl-tyrosine autophosphorylation • protein autophosphorylation • phosphatidylinositol 3-kinase signaling • phosphatidylinositol-mediated signaling • GO:0072468 signal transduction • positive regulation of phosphatidylinositol 3-kinase signaling • glucose homeostasis • positive regulation of protein-containing complex disassembly • positive regulation of MAPK cascade • GO:1903374 anatomical structure development • positive regulation of protein kinase B signaling • cellular response to glucose stimulus • dendritic spine maintenance • amyloid-beta clearance • positive regulation of cold-induced thermogenesis • cellular response to amyloid-beta Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	3480	n/a
Ensembl	ENSG00000140443	n/a
UniProt	P08069	n/a
RefSeq (mRNA)	NM_000875 NM_001291858 NM_152452	n/a
RefSeq (protein)	NP_000866 NP_001278787	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn IGF1R yw IGF1R a elwir hefyd yn Insulin like growth factor 1 receptor (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 15, band 15q26.3.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn IGF1R.

• IGFR
• CD221
• IGFIR
• JTK13

Llyfryddiaeth

• "The Prognostic and Clinicopathological Significance of IGF-1R in NSCLC: a Meta-Analysis. ". Cell Physiol Biochem. 2017. PMID 28946136.
• "Nuclear insulin-like growth factor-1 receptor (IGF1R) displays proliferative and regulatory activities in non-malignant cells. ". PLoS One. 2017. PMID 28945762.
• "Inhibition of the insulin-like growth factor-1 receptor potentiates acute effects of castration in a rat model for prostate cancer growth in bone. ". Clin Exp Metastasis. 2017. PMID 28447314.
• "Stable silencing of IGF1R using Lentiviral-mediated shRNA in HEK293T cells. ". Cell Mol Biol (Noisy-le-grand). 2017. PMID 28364785.
• "Strong association of insulin-like growth factor 1 receptor expression with histologic grade, subtype, and HPV status in penile squamous cell carcinomas: a tissue microarray study of 112 cases.". Virchows Arch. 2017. PMID 28349238.