The 2006 1000 Guineas Stakes was a horse race held at Newmarket Racecourse on Sunday 7 May 2006. It was the 193rd running of the 1000 Guineas. The winner was Pam Sly, Michael Sly and Tom Davies's Speciosa, an Irish-bred bay filly trained by Pam Sly at Thorney in Cambridgeshire and ridden by Micky Fenton. Speciosa's victory was the first in the race for her owner, trainer and jockey. The race was run on soft ground.