The 2012–13 season of Majstrovstvá regiónu is the twentieth season of the fourth-tier football league in Slovakia, since its establishment in 1993. 64 teams are geographically divided into four groups: Majstrovstvá regiónu Bratislava, Majstrovstvá regiónu Západ, Majstrovstvá regiónu Stred and Majstrovstvá regiónu Východ (16 teams each). Teams are playing against teams in their own division only.