The 2021 Hamilton Tiger-Cats season was the 63rd season for the team in the Canadian Football League and their 71st overall. The Tiger-Cats qualified for the playoffs for the third consecutive year following their week 14 win over the BC Lions on November 5, 2021. The team defeated the Montreal Alouettes and Toronto Argonauts in the playoffs to qualify for their 22nd Grey Cup game appearance. In a rematch of the previous season's game against the Winnipeg Blue Bombers, the Tiger-Cats lost to the Blue Bombers 33–25 in overtime in the 108th Grey Cup game.