Božidar Špišić (September 6, 1879 in Sisak - August 31, 1957 in Zagreb) was a Croatian orthopedist and rector of the University of Zagreb. In 1908, Špišić formed the first orthopedic bureau in Croatia, which is seen as the founding of orthopedics in the country. Špišić formed the orthopedic clinic in Zagreb in 1930. He was the rector of the University of Zagreb from 1943 to 1944. In 1946, illness forced him to retire.