The Columbia and Port Deposit Railroad (C&PD) was a railroad that operated in Pennsylvania and Maryland in the 19th and early 20th centuries. It operated a 34-mile long (55 km) main line between Columbia, Pennsylvania, and Port Deposit, Maryland, generally along the eastern shore of the Susquehanna River. It later acquired a branch line to Perryville, Maryland. The C&PD was subsequently purchased by the Pennsylvania Railroad (PRR) and, since the 1999 breakup of Conrail, is owned by Norfolk Southern Railway.