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- 3-Deazaneplanocin A (DZNep, C-c3Ado) is a drug which acts as both a S-adenosylhomocysteine synthesis inhibitor and also a histone methyltransferase EZH2 inhibitor. Studies have shown that it has in vitro against a variety of different tumor cell lines. In studies on mice, the drug was also found to be effective for the treatment of Ebola virus disease, apparently interfering with the Ebola viruses ability to block interferon production, thus restoring the ability of immune system to rid the body of ebolavirus. (en)
- La 3-déazaneplanocine A (DZNep) est un inhibiteur de l'adénosylhomocystéinase, une enzyme qui synthétise la S-adénosylhomocystéine. Des études ont montré qu'elle agit comme médicament anti-cancer des tumeurs colorectales et de l'ovaire. Des études menées sur des souris ont montré que la 3-déazaneplanocine A peut agir contre la maladie à virus Ebola, semble-t-il en interférant avec la capacité du virus Ebola de bloquer la production d'interféron pour échapper au système immunitaire. (fr)
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- (1S,2R,5R)-5-(6-Amino-9H-purin-9-yl)-3-(hydroxymethyl)cyclopent-3-ene-1,2-diol (en)
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- 3-Deazaneplanocin A (DZNep, C-c3Ado) is a drug which acts as both a S-adenosylhomocysteine synthesis inhibitor and also a histone methyltransferase EZH2 inhibitor. Studies have shown that it has in vitro against a variety of different tumor cell lines. In studies on mice, the drug was also found to be effective for the treatment of Ebola virus disease, apparently interfering with the Ebola viruses ability to block interferon production, thus restoring the ability of immune system to rid the body of ebolavirus. (en)
- La 3-déazaneplanocine A (DZNep) est un inhibiteur de l'adénosylhomocystéinase, une enzyme qui synthétise la S-adénosylhomocystéine. Des études ont montré qu'elle agit comme médicament anti-cancer des tumeurs colorectales et de l'ovaire. Des études menées sur des souris ont montré que la 3-déazaneplanocine A peut agir contre la maladie à virus Ebola, semble-t-il en interférant avec la capacité du virus Ebola de bloquer la production d'interféron pour échapper au système immunitaire. (fr)
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- 3-Deazaneplanocin A (en)
- 3-Déazaneplanocine A (fr)
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