Mexican Spitfire at Sea is a 1942 American comedy film directed by Leslie Goodwins and written by Charles E. Roberts and Jerry Cady. It is the fourth film in the Mexican Spitfire series, which began in 1939. The film stars Lupe Vélez, Leon Errol, Charles "Buddy" Rogers, ZaSu Pitts, Elisabeth Risdon, and Florence Bates. The film was released on March 13, 1942, by RKO Radio Pictures.