Topological analysis of 3D cell nuclei using finite element template-based spherical mapping

E. Gladilin; S. Goetze; J. Mateos-Langerak; R. van Driel; R. Eils; K. Rohr

doi:10.1117/12.650260

15 March 2006 Topological analysis of 3D cell nuclei using finite element template-based spherical mapping

E. Gladilin, S. Goetze, J. Mateos-Langerak, R. van Driel, R. Eils, K. Rohr

Proceedings Volume 6144, Medical Imaging 2006: Image Processing; 61444V (2006) https://doi.org/10.1117/12.650260
Event: Medical Imaging, 2006, San Diego, California, United States

Abstract

Topological analysis of cells and subcellular structures on the basis of image data is one of the major trends in modern quantitative biology. However, due to the dynamic nature of cell biology, the optical appearance of different cells or even time series of the same cell is undergoing substantial variations in shape and texture which makes the analysis of image data a non-trivial task. In the absence of canonical invariances, a natural approach to the normalization of cell images consists in dimension reduction of the 3D problem by means of spherical mapping which enables the analysis of targeted regions in terms of radial distances. In this work, we present a finite element template-based approach for physically-base spherical mapping which has been applied for topological analysis of confocal laser scanning microscopy images of cell nuclei.

Citation Download Citation

E. Gladilin, S. Goetze, J. Mateos-Langerak, R. van Driel, R. Eils, and K. Rohr "Topological analysis of 3D cell nuclei using finite element template-based spherical mapping", Proc. SPIE 6144, Medical Imaging 2006: Image Processing, 61444V (15 March 2006); https://doi.org/10.1117/12.650260

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available